Advanced Imaging Platform (AIP) https://www.heika-research.de/de de High-throughput selective cell isolation based on imprinted microfluidics and fluorescence microscopy https://www.heika-research.de/en/research/advanced-imaging-platform-aip/high-throughput-selective-cell-isolation-based-imprinted <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--project.html.twig x field--node--title.html.twig * field--node--project.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">High-throughput selective cell isolation based on imprinted microfluidics and fluorescence microscopy</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--uid--project.html.twig x field--node--uid.html.twig * field--node--project.html.twig * field--uid.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--uid.html.twig' --> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'username' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/user/username.html.twig' --> <span lang="" about="/index.php/de/user/32" typeof="schema:Person" property="schema:name" datatype="">Regine Kleber</span> <!-- END OUTPUT from 'core/themes/classy/templates/user/username.html.twig' --> </span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--uid.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--created--project.html.twig x field--node--created.html.twig * field--node--project.html.twig * field--created.html.twig * field--created.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--created.html.twig' --> <span class="field field--name-created field--type-created field--label-hidden">Mo, 30.07.2018 - 13:11</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--created.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-introduction-image--project.html.twig * field--node--field-introduction-image.html.twig * field--node--project.html.twig * field--field-introduction-image.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-introduction-image field--type-entity-reference field--label-hidden field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'media' --> <!-- FILE NAME SUGGESTIONS: * media--source-image.html.twig * media--image--introduction-image.html.twig * media--image.html.twig * media--introduction-image.html.twig x media.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/content/media.html.twig' --> <article class="media media--type-image media--view-mode-introduction-image"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--media--field-media-image--image.html.twig * field--media--field-media-image.html.twig * field--media--image.html.twig * field--field-media-image.html.twig * field--image.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'responsive_image_formatter' --> <!-- BEGIN OUTPUT from 'core/themes/stable/templates/field/responsive-image-formatter.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'responsive_image' --> <!-- BEGIN OUTPUT from 'core/themes/stable/templates/field/responsive-image.html.twig' --> <picture> <source srcset="/sites/default/files/styles/introduction_image_1x_desktop/public/2018-08/IMG_2025.JPG?h=71976bb4&amp;itok=_5AgZSW4 1x, /sites/default/files/styles/introduction_image_2x_desktop/public/2018-08/IMG_2025.JPG?h=71976bb4&amp;itok=SjBwOhGj 2x" media="all and (min-width: 769px)" type="image/jpeg"/> <source srcset="/sites/default/files/styles/introduction_image_1x_tablet/public/2018-08/IMG_2025.JPG?h=71976bb4&amp;itok=p_GxV4Oh 1x, /sites/default/files/styles/introduction_image_2x_tablet/public/2018-08/IMG_2025.JPG?h=71976bb4&amp;itok=sgEWYHBS 2x" media="all and (min-width: 481px) and (max-width: 768px)" type="image/jpeg"/> <source srcset="/sites/default/files/styles/introduction_image_1x_phone/public/2018-08/IMG_2025.JPG?h=71976bb4&amp;itok=0wkkDt-3 1x, /sites/default/files/styles/introduction_image_2x_phone/public/2018-08/IMG_2025.JPG?h=71976bb4&amp;itok=xHreioFq 2x" media="all and (max-width: 480px)" type="image/jpeg"/> <!-- THEME DEBUG --> <!-- THEME HOOK: 'image' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/image.html.twig' --> <img src="/sites/default/files/styles/introduction_image_1x_desktop/public/2018-08/IMG_2025.JPG?h=71976bb4&amp;itok=_5AgZSW4" alt="Presentation on HEiKA Day 2018" typeof="foaf:Image" /> <!-- END OUTPUT from 'core/themes/classy/templates/field/image.html.twig' --> </picture> <!-- END OUTPUT from 'core/themes/stable/templates/field/responsive-image.html.twig' --> <!-- END OUTPUT from 'core/themes/stable/templates/field/responsive-image-formatter.html.twig' --> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--media--field-copyright--image.html.twig * field--media--field-copyright.html.twig * field--media--image.html.twig * field--field-copyright.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-copyright field--type-string field--label-visually_hidden"> <div class="field__label visually-hidden">Copyright</div> <div class="field__item">Heika</div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> </article> <!-- END OUTPUT from 'core/themes/classy/templates/content/media.html.twig' --> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-summary--project.html.twig * field--node--field-summary.html.twig * field--node--project.html.twig * field--field-summary.html.twig x field--text-long.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--text-long.html.twig' --> <div class="clearfix text-formatted field field--name-field-summary field--type-text-long field--label-hidden field__item"><p style="text-align:justify"><span style="font-size:11pt"><span style="text-autospace:none"><span style="line-height:115%"><span style="font-family:&quot;Cambria&quot;,serif"><span lang="EN-GB" style="font-family:&quot;Arial&quot;,sans-serif" xml:lang="EN-GB">Functional analysis of biological samples for diagnostic or research purposes often requires the isolation of small cell populations from heterogeneous mixtures. Traditionally, this is accomplished using either flow cytometry or microdissection/manipulation performed using microscopes. Flow cytometry-based cell sorters provide unmatched throughput, but the information output is limited when it comes to subcellular organization and cellular structures. This information can be collected using microscopy-based cell enrichment methods. However, these methods lack the required throughput for the analysis of large, complex samples and usually require expensive equipment. Within the context of this interdisciplinary project, we have combined a commercial fluorescence microscope and a laser ablation system to create an instrument with the ability to image and isolate highly parameterized subpopulations of cell mixtures in real time. Selective cell isolation is achieved by directing a high-energy laser beam onto cells exhibiting an unwanted phenotype, killing them, and thereby removing them from the pool. The remaining subpopulation of cells is collected alive for further propagation and analysis. This process has been completely automated and can be repeated as many times as necessary until the desired cell population has been isolated. In order to achieve high throughput, imprinted microfluidic chips have been developed for cell delivery, imaging, and collection. The microfluidic chips were designed, fabricated, and tested in house. The developed cell isolation microscope is being tested for use within the context of basic cell biology, but its impact is expected to extend beyond basic research and into applications such as drug development and cancer research</span><span lang="EN-GB" style="font-size:10.0pt" xml:lang="EN-GB"><span style="line-height:115%"><span style="font-family:&quot;Arial&quot;,sans-serif">.</span></span></span></span></span></span></span></p> </div> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--text-long.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: x links--node.html.twig x links--node.html.twig * links.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/content/links--node.html.twig' --> <!-- END OUTPUT from 'core/themes/classy/templates/content/links--node.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-bridges--project.html.twig * field--node--field-research-bridges.html.twig * field--node--project.html.twig * field--field-research-bridges.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-research-bridges field--type-entity-reference field--label-above"> <div class="field__label">Forschungsbrücken</div> <div class="field__items"> <div class="field__item"><a href="/index.php/en/research/advanced-imaging-platform-aip" hreflang="en">Advanced Imaging Platform (AIP)</a></div> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: x field--node--field-start-date--project.html.twig * field--node--field-start-date.html.twig * field--node--project.html.twig * field--field-start-date.html.twig * field--datetime.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field--node--field-start-date--project.html.twig' --> <div class="field field--name-field-start-date field--type-datetime field--label-above"> <div class="field__label">Start date</div> <div class="field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> <time datetime="2018-01-01T12:00:00Z" class="datetime">01.01.2018</time> <!-- END OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field--node--field-start-date--project.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-end-date--project.html.twig * field--node--field-end-date.html.twig * field--node--project.html.twig * field--field-end-date.html.twig * field--datetime.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-end-date field--type-datetime field--label-hidden field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> <time datetime="2018-12-31T12:00:00Z" class="datetime">31.12.2018</time> <!-- END OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-contact-person--project.html.twig * field--node--field-contact-person.html.twig * field--node--project.html.twig x field--field-contact-person.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field--field-contact-person.html.twig' --> <div class="field field--name-field-contact-person field--type-entity-reference field--label-above"> <div class="field__label"><h3>Project management</h3></div> <div class="field__items"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'node' --> <!-- FILE NAME SUGGESTIONS: * node--75--teaser.html.twig * node--75.html.twig x node--people-profile--teaser.html.twig * node--people-profile.html.twig * node--teaser.html.twig * node.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <article data-history-node-id="75" role="article" lang="en" about="/en/dr-iordania-constantinou" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/en/dr-iordania-constantinou" rel="bookmark"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--people-profile.html.twig x field--node--title.html.twig * field--node--people-profile.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Dr. Iordania Constantinou</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> </a> </h2> </div> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-institute--people-profile.html.twig * field--node--field-institute.html.twig * field--node--people-profile.html.twig * field--field-institute.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH)</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-facility--people-profile.html.twig * field--node--field-facility.html.twig * field--node--people-profile.html.twig * field--field-facility.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">Heidelberg University</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-link--people-profile.html.twig * field--node--field-link.html.twig * field--node--people-profile.html.twig * field--field-link.html.twig * field--link.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="https://www.zmbh.uni-heidelberg.de/Knop/staff.html">Knop Lab @ ZMBH</a></div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> </div> </div> </article> <!-- END OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'node' --> <!-- FILE NAME SUGGESTIONS: * node--76--teaser.html.twig * node--76.html.twig x node--people-profile--teaser.html.twig * node--people-profile.html.twig * node--teaser.html.twig * node.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <article data-history-node-id="76" role="article" lang="en" about="/index.php/en/dr-dario-mager" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/index.php/en/dr-dario-mager" rel="bookmark"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--people-profile.html.twig x field--node--title.html.twig * field--node--people-profile.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Dr. Dario Mager</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> </a> </h2> </div> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-institute--people-profile.html.twig * field--node--field-institute.html.twig * field--node--people-profile.html.twig * field--field-institute.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Institute of Microstructure Technology (IMT)</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-facility--people-profile.html.twig * field--node--field-facility.html.twig * field--node--people-profile.html.twig * field--field-facility.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">Karlsruhe Institute of Technology</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-link--people-profile.html.twig * field--node--field-link.html.twig * field--node--people-profile.html.twig * field--field-link.html.twig * field--link.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="https://www.imt.kit.edu/mager.php">Mager Group</a></div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> </div> </div> </article> <!-- END OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field--field-contact-person.html.twig' --> Mon, 30 Jul 2018 11:11:01 +0000 Regine Kleber 77 at https://www.heika-research.de Synthesis of single cell, single molecule RNA probes for the detection of enogenous microRNAs in human cancer to dentify metastatically relevant cance cell fractions in heterogenous tumors https://www.heika-research.de/en/research/advanced-imaging-platform-aip/synthesis-single-cell-single-molecule-rna-probes-detection <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--project.html.twig x field--node--title.html.twig * field--node--project.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Synthesis of single cell, single molecule RNA probes for the detection of enogenous microRNAs in human cancer to dentify metastatically relevant cance cell fractions in heterogenous tumors</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--uid--project.html.twig x field--node--uid.html.twig * field--node--project.html.twig * field--uid.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--uid.html.twig' --> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'username' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/user/username.html.twig' --> <span lang="" about="/index.php/de/user/32" typeof="schema:Person" property="schema:name" datatype="">Regine Kleber</span> <!-- END OUTPUT from 'core/themes/classy/templates/user/username.html.twig' --> </span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--uid.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--created--project.html.twig x field--node--created.html.twig * field--node--project.html.twig * field--created.html.twig * field--created.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--created.html.twig' --> <span class="field field--name-created field--type-created field--label-hidden">Mo, 30.07.2018 - 13:16</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--created.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-summary--project.html.twig * field--node--field-summary.html.twig * field--node--project.html.twig * field--field-summary.html.twig x field--text-long.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--text-long.html.twig' --> <div class="clearfix text-formatted field field--name-field-summary field--type-text-long field--label-hidden field__item"><p style="text-align:justify"><span style="font-size:11pt"><span style="line-height:115%"><span style="font-family:&quot;Cambria&quot;,serif"><span lang="EN-US" style="font-family:&quot;Arial&quot;,sans-serif" xml:lang="EN-US">It is estimated that metastasis is the main reason in about 90% of cancer deaths. Therefore, a better understanding of the key molecular players in determining and regulating this process is urgently needed. Previous studies in fixed cells in culture have shown, that certain microRNA (miRNA) molecules are in significantly higher numbers in exosomes of highly metastatic cells in comparison to low metastatic cells [1]. However, in real patient tissues, issues such as the cell h<span style="color:black">eterogeneity in the primary tumor and the definition of metastatic clones are a major challenge in the context of metastasis.</span></span></span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="line-height:115%"><span style="font-family:&quot;Cambria&quot;,serif"><span lang="EN-US" style="font-family:&quot;Arial&quot;,sans-serif" xml:lang="EN-US">In this project, we used human colon tissue sections, which are relevant samples for routine diagnosis in pathology, to study the chromatin nanostructure of different cells types and the presence and distribution of five metastatically relevant miRNAs (miR-21, miR-31, mi-R210, miR-135b and miR-218).</span></span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="line-height:115%"><span style="font-family:&quot;Cambria&quot;,serif"><span lang="EN-US" style="font-family:&quot;Arial&quot;,sans-serif" xml:lang="EN-US">DNA-sequences complementary to the above-mentioned metastatically relevant miRNA were synthesized and modified so that a fluorescent dye was incorporated in the middle of the sequence. Human formalin-fixed paraffin-embedded (FFPE) colon tissues were sliced into 10</span><span lang="EN-US" style="font-family:Symbol" xml:lang="EN-US">m</span><span lang="EN-US" style="font-family:&quot;Arial&quot;,sans-serif" xml:lang="EN-US">m thick sections and fluorescent in situ hybridization (FISH) with the different miRNA probes was performed at normal and colon cancer tissue sections followed by a subsequent nuclear counterstain with Sytox Orange (SO). </span></span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="line-height:115%"><span style="font-family:&quot;Cambria&quot;,serif"><span lang="EN-US" style="font-family:&quot;Arial&quot;,sans-serif" xml:lang="EN-US">Confocal images allowed the quantification of the different miRNAs in human tissue samples. Pro-metastatic miRNAs were found in significantly higher numbers of molecules in epithelial cells of tumor samples in comparison with their normal counterparts. More variability and a strong patient-associated quantification was observed for miR-218, an anti-metastatic miRNA. </span></span></span></span></p> <p><span lang="EN-US" style="font-size:11.0pt" xml:lang="EN-US"><span style="line-height:115%"><span style="font-family:&quot;Arial&quot;,sans-serif">We successfully performed, for the first time, single molecule localization microscopy (SMLM) for the chromatin nanostructure and human microRNAs at the single molecule level in routine patient tissues. Preliminary results showed the distribution of miR-21 in the periphery and the inside of a tumor cell nucleus. Vesicle-like structures outside the nuclear region of sizes ranging from 110 to 240 nm appear to be loaded with this miRNA. </span></span></span></p> </div> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--text-long.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: x links--node.html.twig x links--node.html.twig * links.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/content/links--node.html.twig' --> <!-- END OUTPUT from 'core/themes/classy/templates/content/links--node.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-bridges--project.html.twig * field--node--field-research-bridges.html.twig * field--node--project.html.twig * field--field-research-bridges.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-research-bridges field--type-entity-reference field--label-above"> <div class="field__label">Forschungsbrücken</div> <div class="field__items"> <div class="field__item"><a href="/index.php/en/research/advanced-imaging-platform-aip" hreflang="en">Advanced Imaging Platform (AIP)</a></div> <div class="field__item"><a href="/index.php/en/research/synthetic-biology-sb" hreflang="en">Synthetic Biology (SB)</a></div> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: x field--node--field-start-date--project.html.twig * field--node--field-start-date.html.twig * field--node--project.html.twig * field--field-start-date.html.twig * field--datetime.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field--node--field-start-date--project.html.twig' --> <div class="field field--name-field-start-date field--type-datetime field--label-above"> <div class="field__label">Start date</div> <div class="field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> <time datetime="2018-01-01T12:00:00Z" class="datetime">01.01.2018</time> <!-- END OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field--node--field-start-date--project.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-end-date--project.html.twig * field--node--field-end-date.html.twig * field--node--project.html.twig * field--field-end-date.html.twig * field--datetime.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-end-date field--type-datetime field--label-hidden field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> <time datetime="2018-12-31T12:00:00Z" class="datetime">31.12.2018</time> <!-- END OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-contact-person--project.html.twig * field--node--field-contact-person.html.twig * field--node--project.html.twig x field--field-contact-person.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field--field-contact-person.html.twig' --> <div class="field field--name-field-contact-person field--type-entity-reference field--label-above"> <div class="field__label"><h3>Project management</h3></div> <div class="field__items"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'node' --> <!-- FILE NAME SUGGESTIONS: * node--78--teaser.html.twig * node--78.html.twig x node--people-profile--teaser.html.twig * node--people-profile.html.twig * node--teaser.html.twig * node.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <article data-history-node-id="78" role="article" lang="en" about="/index.php/en/prof-dr-heike-allgayer" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/index.php/en/prof-dr-heike-allgayer" rel="bookmark"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--people-profile.html.twig x field--node--title.html.twig * field--node--people-profile.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Prof. Dr. Heike Allgayer</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> </a> </h2> </div> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-institute--people-profile.html.twig * field--node--field-institute.html.twig * field--node--people-profile.html.twig * field--field-institute.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Medical Faculty Mannheim </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-facility--people-profile.html.twig * field--node--field-facility.html.twig * field--node--people-profile.html.twig * field--field-facility.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">Heidelberg University</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-link--people-profile.html.twig * field--node--field-link.html.twig * field--node--people-profile.html.twig * field--field-link.html.twig * field--link.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="https://www.umm.uni-heidelberg.de/inst/exp_chir/index_e.html">Experimental Surgery, Cancer Metastasis </a></div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> </div> </div> </article> <!-- END OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'node' --> <!-- FILE NAME SUGGESTIONS: * node--79--teaser.html.twig * node--79.html.twig x node--people-profile--teaser.html.twig * node--people-profile.html.twig * node--teaser.html.twig * node.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <article data-history-node-id="79" role="article" lang="en" about="/en/prof-dr-hans-achim-wagenknecht" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/en/prof-dr-hans-achim-wagenknecht" rel="bookmark"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--people-profile.html.twig x field--node--title.html.twig * field--node--people-profile.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Prof. Dr. Hans-Achim Wagenknecht</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> </a> </h2> </div> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-institute--people-profile.html.twig * field--node--field-institute.html.twig * field--node--people-profile.html.twig * field--field-institute.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Institute for Organic Chemistry </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-facility--people-profile.html.twig * field--node--field-facility.html.twig * field--node--people-profile.html.twig * field--field-facility.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">Karlsruhe Institute of Technology</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-link--people-profile.html.twig * field--node--field-link.html.twig * field--node--people-profile.html.twig * field--field-link.html.twig * field--link.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="http://www.ioc.kit.edu/wagenknecht/26.php">Wagenknecht Group</a></div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> </div> </div> </article> <!-- END OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field--field-contact-person.html.twig' --> Mon, 30 Jul 2018 11:16:37 +0000 Regine Kleber 80 at https://www.heika-research.de In vitro and in vivo Monitoring of Dopamine Levels in Neural Tissues using Novel Zeolite-based Chemosensors https://www.heika-research.de/en/research/advanced-imaging-platform-aip/vitro-and-vivo-monitoring-dopamine-levels-neural-tissues <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--project.html.twig x field--node--title.html.twig * field--node--project.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">In vitro and in vivo Monitoring of Dopamine Levels in Neural Tissues using Novel Zeolite-based Chemosensors</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--uid--project.html.twig x field--node--uid.html.twig * field--node--project.html.twig * field--uid.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--uid.html.twig' --> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'username' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/user/username.html.twig' --> <span lang="" about="/index.php/de/user/32" typeof="schema:Person" property="schema:name" datatype="">Regine Kleber</span> <!-- END OUTPUT from 'core/themes/classy/templates/user/username.html.twig' --> </span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--uid.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--created--project.html.twig x field--node--created.html.twig * field--node--project.html.twig * field--created.html.twig * field--created.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--created.html.twig' --> <span class="field field--name-created field--type-created field--label-hidden">Mo, 12.11.2018 - 17:00</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--created.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-summary--project.html.twig * field--node--field-summary.html.twig * field--node--project.html.twig * field--field-summary.html.twig x field--text-long.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--text-long.html.twig' --> <div class="clearfix text-formatted field field--name-field-summary field--type-text-long field--label-hidden field__item"><p><span><span><span><span><span lang="EN-US" xml:lang="EN-US" xml:lang="EN-US">We propose the application of artificial neurotransmitter receptors (ANR) for the monitoring of dopamine levels in neuronal tissues as well as in prefrontal cortex and basal nuclei of intact mice. In the first step, existing and newly prepared fluorescent ANRs will be tested under the conditions of 2-photon microscopy and single photon microendoscopic imaging. Parameters that will be changed are the zeolite and dye identity, dye loading, surface functionalization and the size of the zeolites. Kinetic rates of signal appearance, which is related to the neurotransmitter uptake rates, will be measured. Additional ANRs will be prepared that contain widely used 2-photon absorbing dyes such as DAPI, either directly as the “indicator dye” or as the “antenna dye” (in combination with FRET to the indicator dye). The sensing performance of such ANRs for different aromatic amine neurotransmitters will be evaluated in buffers and biological media (e.g. cell culture media). Promising ANR candidates will be then tested first by application to acute brain slices using single-photon and two-photon excitation. To image dopamine signalling in the intact brain, ANRs will be directly delivered to the brain region of interest by stereotaxic injection.</span></span></span></span></span></p> <p><span lang="EN-US" xml:lang="EN-US" xml:lang="EN-US"><span><span>Regions of the prefrontal cortex accessible to two-photon microscopy will be examined with in vivo two-photon microscopy. Deep regions such as the striatum or nucleus accumbens will be imaged via implanted microendoscopes using either two-photon imaging in head-fixed mice or single-photon imaging with miniature microscopes in freely behaving mice. This approach promises systemic readouts of dopamine action in the context of the behaving animal, allowing to directly link neuronal and circuit mechanisms related to dopamine signalling with distinct behaviours.</span></span></span></p></div> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--text-long.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: x links--node.html.twig x links--node.html.twig * links.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/content/links--node.html.twig' --> <!-- END OUTPUT from 'core/themes/classy/templates/content/links--node.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-bridges--project.html.twig * field--node--field-research-bridges.html.twig * field--node--project.html.twig * field--field-research-bridges.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-research-bridges field--type-entity-reference field--label-above"> <div class="field__label">Forschungsbrücken</div> <div class="field__items"> <div class="field__item"><a href="/index.php/en/research/advanced-imaging-platform-aip" hreflang="en">Advanced Imaging Platform (AIP)</a></div> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: x field--node--field-start-date--project.html.twig * field--node--field-start-date.html.twig * field--node--project.html.twig * field--field-start-date.html.twig * field--datetime.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field--node--field-start-date--project.html.twig' --> <div class="field field--name-field-start-date field--type-datetime field--label-above"> <div class="field__label">Start date</div> <div class="field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> <time datetime="2019-01-01T12:00:00Z" class="datetime">01.01.2019</time> <!-- END OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field--node--field-start-date--project.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-end-date--project.html.twig * field--node--field-end-date.html.twig * field--node--project.html.twig * field--field-end-date.html.twig * field--datetime.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-end-date field--type-datetime field--label-hidden field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> <time datetime="2019-12-31T12:00:00Z" class="datetime">31.12.2019</time> <!-- END OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-contact-person--project.html.twig * field--node--field-contact-person.html.twig * field--node--project.html.twig x field--field-contact-person.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field--field-contact-person.html.twig' --> <div class="field field--name-field-contact-person field--type-entity-reference field--label-above"> <div class="field__label"><h3>Project management</h3></div> <div class="field__items"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'node' --> <!-- FILE NAME SUGGESTIONS: * node--192--teaser.html.twig * node--192.html.twig x node--people-profile--teaser.html.twig * node--people-profile.html.twig * node--teaser.html.twig * node.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <article data-history-node-id="192" role="article" lang="en" about="/index.php/en/prof-dr-thomas-kuner" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/index.php/en/prof-dr-thomas-kuner" rel="bookmark"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--people-profile.html.twig x field--node--title.html.twig * field--node--people-profile.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Prof. Dr. Thomas Kuner</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> </a> </h2> </div> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-institute--people-profile.html.twig * field--node--field-institute.html.twig * field--node--people-profile.html.twig * field--field-institute.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Institute for Anatomy and Cell Biology</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-facility--people-profile.html.twig * field--node--field-facility.html.twig * field--node--people-profile.html.twig * field--field-facility.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">Heidelberg University</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-link--people-profile.html.twig * field--node--field-link.html.twig * field--node--people-profile.html.twig * field--field-link.html.twig * field--link.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="http://www.ana.uni-heidelberg.de/index.php?id=ag-kuner">Kuner Group</a></div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> </div> </div> </article> <!-- END OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'node' --> <!-- FILE NAME SUGGESTIONS: * node--193--teaser.html.twig * node--193.html.twig x node--people-profile--teaser.html.twig * node--people-profile.html.twig * node--teaser.html.twig * node.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <article data-history-node-id="193" role="article" lang="en" about="/index.php/en/dr-frank-biedermann" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-profile-picture--people-profile.html.twig * field--node--field-profile-picture.html.twig * field--node--people-profile.html.twig * field--field-profile-picture.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-profile-picture field--type-entity-reference field--label-hidden field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'media' --> <!-- FILE NAME SUGGESTIONS: * media--source-image.html.twig * media--image--portrait-image.html.twig * media--image.html.twig * media--portrait-image.html.twig x media.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/content/media.html.twig' --> <article class="media media--type-image media--view-mode-portrait-image"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--media--field-media-image--image.html.twig * field--media--field-media-image.html.twig * field--media--image.html.twig * field--field-media-image.html.twig * field--image.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'responsive_image_formatter' --> <!-- BEGIN OUTPUT from 'core/themes/stable/templates/field/responsive-image-formatter.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'responsive_image' --> <!-- BEGIN OUTPUT from 'core/themes/stable/templates/field/responsive-image.html.twig' --> <picture> <source srcset="/sites/default/files/styles/portrait_1x_tablet/public/2021-02/BD_member_FBiedermann.jpg?h=56d3d675&amp;itok=Te6oZ9IA 1x, /sites/default/files/styles/portrait_2x_tablet/public/2021-02/BD_member_FBiedermann.jpg?h=56d3d675&amp;itok=yGXV_woN 2x" media="all and (min-width: 769px)" type="image/jpeg"/> <source srcset="/sites/default/files/styles/portrait_1x_tablet/public/2021-02/BD_member_FBiedermann.jpg?h=56d3d675&amp;itok=Te6oZ9IA 1x, /sites/default/files/styles/portrait_2x_tablet/public/2021-02/BD_member_FBiedermann.jpg?h=56d3d675&amp;itok=yGXV_woN 2x" media="all and (min-width: 481px) and (max-width: 768px)" type="image/jpeg"/> <source srcset="/sites/default/files/styles/portrait_1x_phone/public/2021-02/BD_member_FBiedermann.jpg?h=56d3d675&amp;itok=xMkkK-PX 1x, /sites/default/files/styles/portrait_1x_tablet/public/2021-02/BD_member_FBiedermann.jpg?h=56d3d675&amp;itok=Te6oZ9IA 2x" media="all and (max-width: 480px)" type="image/jpeg"/> <!-- THEME DEBUG --> <!-- THEME HOOK: 'image' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/image.html.twig' --> <img src="/sites/default/files/styles/portrait_1x_tablet/public/2021-02/BD_member_FBiedermann.jpg?h=56d3d675&amp;itok=Te6oZ9IA" alt="Photo Frank Biedermann" typeof="foaf:Image" /> <!-- END OUTPUT from 'core/themes/classy/templates/field/image.html.twig' --> </picture> <!-- END OUTPUT from 'core/themes/stable/templates/field/responsive-image.html.twig' --> <!-- END OUTPUT from 'core/themes/stable/templates/field/responsive-image-formatter.html.twig' --> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> </article> <!-- END OUTPUT from 'core/themes/classy/templates/content/media.html.twig' --> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="content-container"> <div class="header-container"> <h2> <a href="/index.php/en/dr-frank-biedermann" rel="bookmark"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--people-profile.html.twig x field--node--title.html.twig * field--node--people-profile.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Dr. Frank Biedermann</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> </a> </h2> </div> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-institute--people-profile.html.twig * field--node--field-institute.html.twig * field--node--people-profile.html.twig * field--field-institute.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Institute of Nanotechnology</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-facility--people-profile.html.twig * field--node--field-facility.html.twig * field--node--people-profile.html.twig * field--field-facility.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">Karlsruhe Institute of Technolgoy</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-link--people-profile.html.twig * field--node--field-link.html.twig * field--node--people-profile.html.twig * field--field-link.html.twig * field--link.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="https://www.int.kit.edu/staff_2034.php">Research Group Biedermann</a></div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> </div> </div> </article> <!-- END OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field--field-contact-person.html.twig' --> Mon, 12 Nov 2018 16:00:21 +0000 Regine Kleber 207 at https://www.heika-research.de Modular shining architectures for cellular imaging https://www.heika-research.de/en/research/advanced-imaging-platform-aip/modular-shining-architectures-cellular-imaging <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--project.html.twig x field--node--title.html.twig * field--node--project.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Modular shining architectures for cellular imaging</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--uid--project.html.twig x field--node--uid.html.twig * field--node--project.html.twig * field--uid.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--uid.html.twig' --> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'username' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/user/username.html.twig' --> <span lang="" about="/index.php/de/user/32" typeof="schema:Person" property="schema:name" datatype="">Regine Kleber</span> <!-- END OUTPUT from 'core/themes/classy/templates/user/username.html.twig' --> </span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--uid.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--created--project.html.twig x field--node--created.html.twig * field--node--project.html.twig * field--created.html.twig * field--created.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--created.html.twig' --> <span class="field field--name-created field--type-created field--label-hidden">Mo, 12.11.2018 - 17:06</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--created.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-summary--project.html.twig * field--node--field-summary.html.twig * field--node--project.html.twig * field--field-summary.html.twig x field--text-long.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--text-long.html.twig' --> <div class="clearfix text-formatted field field--name-field-summary field--type-text-long field--label-hidden field__item"><p><span><span><span><span><span lang="EN-US" xml:lang="EN-US" xml:lang="EN-US">In this project, we will design and develop a modular approach to address target-specifically accumulating conjugates consisting of bright fluorescent dyes and target-affine peptides. For this, we will create fluorescent dyes with bright fluorescence in the optimal optical imaging window (targeting the IR range) and derivatize them with functional groups to obtain substances which can be efficiently introduced in various bioactive molecules such as - but not limited to - receptor-affine peptides. On the other side, we will synthesize receptor-specific peptides being able to efficiently address our model receptor system (gastrin-releasing peptide receptor) and chemically modify them to achieve a high stability and appropriate hydrophilicity (depending on the respective fluorescent dye used) to obtain fluorescent drugs with high potential for prospective in vivo imaging.</span></span></span></span></span></p> <p><span><span><span><span><span lang="EN-US" xml:lang="EN-US" xml:lang="EN-US">For this purpose, chemical developments have to be carried out to establish an approach yielding substances with high future potential. The developed model ligands will be characterized regarding their optical properties as well as their hydrophilicity and in vitro stability.</span></span></span></span></span></p> <p><span><span><span><span><span lang="EN-US" xml:lang="EN-US" xml:lang="EN-US">This project complements the activities of the Bräse group within the GRK 2939 - the Wängler group has profound expertise in particular in in vitro evaluations and tumor mouse models which is not present in this depth in the GRK.</span></span></span></span></span></p> <p><span lang="EN-US" xml:lang="EN-US" xml:lang="EN-US"><span><span>In addition, the Wängler group adds radiochemistry expertise lacking in Karlsruhe and its GRK.</span></span></span></p></div> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--text-long.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: x links--node.html.twig x links--node.html.twig * links.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/content/links--node.html.twig' --> <!-- END OUTPUT from 'core/themes/classy/templates/content/links--node.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-bridges--project.html.twig * field--node--field-research-bridges.html.twig * field--node--project.html.twig * field--field-research-bridges.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-research-bridges field--type-entity-reference field--label-above"> <div class="field__label">Forschungsbrücken</div> <div class="field__items"> <div class="field__item"><a href="/index.php/en/research/advanced-imaging-platform-aip" hreflang="en">Advanced Imaging Platform (AIP)</a></div> <div class="field__item"><a href="/index.php/en/research/synthetic-biology-sb" hreflang="en">Synthetic Biology (SB)</a></div> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: x field--node--field-start-date--project.html.twig * field--node--field-start-date.html.twig * field--node--project.html.twig * field--field-start-date.html.twig * field--datetime.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field--node--field-start-date--project.html.twig' --> <div class="field field--name-field-start-date field--type-datetime field--label-above"> <div class="field__label">Start date</div> <div class="field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> <time datetime="2019-01-01T12:00:00Z" class="datetime">01.01.2019</time> <!-- END OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field--node--field-start-date--project.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-end-date--project.html.twig * field--node--field-end-date.html.twig * field--node--project.html.twig * field--field-end-date.html.twig * field--datetime.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-end-date field--type-datetime field--label-hidden field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> <time datetime="2019-12-31T12:00:00Z" class="datetime">31.12.2019</time> <!-- END OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-contact-person--project.html.twig * field--node--field-contact-person.html.twig * field--node--project.html.twig x field--field-contact-person.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field--field-contact-person.html.twig' --> <div class="field field--name-field-contact-person field--type-entity-reference field--label-above"> <div class="field__label"><h3>Project management</h3></div> <div class="field__items"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'node' --> <!-- FILE NAME SUGGESTIONS: * node--194--teaser.html.twig * node--194.html.twig x node--people-profile--teaser.html.twig * node--people-profile.html.twig * node--teaser.html.twig * node.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <article data-history-node-id="194" role="article" lang="en" about="/index.php/en/prof-dr-carmen-wangler" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/index.php/en/prof-dr-carmen-wangler" rel="bookmark"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--people-profile.html.twig x field--node--title.html.twig * field--node--people-profile.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Prof. Dr. Carmen Wängler</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> </a> </h2> </div> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-institute--people-profile.html.twig * field--node--field-institute.html.twig * field--node--people-profile.html.twig * field--field-institute.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Institut für Klinische Radiologie und Nuklearmedizin</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-facility--people-profile.html.twig * field--node--field-facility.html.twig * field--node--people-profile.html.twig * field--field-facility.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">Heidelberg University</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-link--people-profile.html.twig * field--node--field-link.html.twig * field--node--people-profile.html.twig * field--field-link.html.twig * field--link.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="https://www.umm.uni-heidelberg.de/inst/radchem/Mitarbeiter_Waengler_Carmen.html">CV Carmen Wängler</a></div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> </div> </div> </article> <!-- END OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'node' --> <!-- FILE NAME SUGGESTIONS: * node--82--teaser.html.twig * node--82.html.twig x node--people-profile--teaser.html.twig * node--people-profile.html.twig * node--teaser.html.twig * node.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <article data-history-node-id="82" role="article" lang="en" about="/en/prof-dr-stefan-brase" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-profile-picture--people-profile.html.twig * field--node--field-profile-picture.html.twig * field--node--people-profile.html.twig * field--field-profile-picture.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-profile-picture field--type-entity-reference field--label-hidden field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'media' --> <!-- FILE NAME SUGGESTIONS: * media--source-image.html.twig * media--image--portrait-image.html.twig * media--image.html.twig * media--portrait-image.html.twig x media.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/content/media.html.twig' --> <article class="media media--type-image media--view-mode-portrait-image"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--media--field-media-image--image.html.twig * field--media--field-media-image.html.twig * field--media--image.html.twig * field--field-media-image.html.twig * field--image.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'responsive_image_formatter' --> <!-- BEGIN OUTPUT from 'core/themes/stable/templates/field/responsive-image-formatter.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'responsive_image' --> <!-- BEGIN OUTPUT from 'core/themes/stable/templates/field/responsive-image.html.twig' --> <picture> <source srcset="/sites/default/files/styles/portrait_1x_tablet/public/2022-02/BD_member_SBr%C3%A4se-2022.jpg?h=94c5bb61&amp;itok=tRDkEn32 1x, /sites/default/files/styles/portrait_2x_tablet/public/2022-02/BD_member_SBr%C3%A4se-2022.jpg?h=94c5bb61&amp;itok=8xzVPZUT 2x" media="all and (min-width: 769px)" type="image/jpeg"/> <source srcset="/sites/default/files/styles/portrait_1x_tablet/public/2022-02/BD_member_SBr%C3%A4se-2022.jpg?h=94c5bb61&amp;itok=tRDkEn32 1x, /sites/default/files/styles/portrait_2x_tablet/public/2022-02/BD_member_SBr%C3%A4se-2022.jpg?h=94c5bb61&amp;itok=8xzVPZUT 2x" media="all and (min-width: 481px) and (max-width: 768px)" type="image/jpeg"/> <source srcset="/sites/default/files/styles/portrait_1x_phone/public/2022-02/BD_member_SBr%C3%A4se-2022.jpg?h=94c5bb61&amp;itok=CDIXD_tE 1x, /sites/default/files/styles/portrait_1x_tablet/public/2022-02/BD_member_SBr%C3%A4se-2022.jpg?h=94c5bb61&amp;itok=tRDkEn32 2x" media="all and (max-width: 480px)" type="image/jpeg"/> <!-- THEME DEBUG --> <!-- THEME HOOK: 'image' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/image.html.twig' --> <img src="/sites/default/files/styles/portrait_1x_tablet/public/2022-02/BD_member_SBr%C3%A4se-2022.jpg?h=94c5bb61&amp;itok=tRDkEn32" alt="Portrait Stefan Bräse" typeof="foaf:Image" /> <!-- END OUTPUT from 'core/themes/classy/templates/field/image.html.twig' --> </picture> <!-- END OUTPUT from 'core/themes/stable/templates/field/responsive-image.html.twig' --> <!-- END OUTPUT from 'core/themes/stable/templates/field/responsive-image-formatter.html.twig' --> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> </article> <!-- END OUTPUT from 'core/themes/classy/templates/content/media.html.twig' --> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="content-container"> <div class="header-container"> <h2> <a href="/en/prof-dr-stefan-brase" rel="bookmark"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--people-profile.html.twig x field--node--title.html.twig * field--node--people-profile.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Prof. Dr. Stefan Bräse</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> </a> </h2> </div> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-function-1--people-profile.html.twig * field--node--field-function-1.html.twig * field--node--people-profile.html.twig * field--field-function-1.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-function-1 field--type-string field--label-hidden field__item">Director Research Bridge SB</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-institute--people-profile.html.twig * field--node--field-institute.html.twig * field--node--people-profile.html.twig * field--field-institute.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Institute of Organic Chemistry (IOC)</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-facility--people-profile.html.twig * field--node--field-facility.html.twig * field--node--people-profile.html.twig * field--field-facility.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">Karlsruhe Institute of Technology</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-link--people-profile.html.twig * field--node--field-link.html.twig * field--node--people-profile.html.twig * field--field-link.html.twig * field--link.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="http://www.ioc.kit.edu/braese/english/26.php">Research Group Bräse</a></div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> </div> </div> </article> <!-- END OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field--field-contact-person.html.twig' --> Mon, 12 Nov 2018 16:06:46 +0000 Regine Kleber 208 at https://www.heika-research.de Three-dimensional imaging of gene expression patterns by x-ray computed tomography https://www.heika-research.de/en/research/advanced-imaging-platform-aip/three-dimensional-imaging-gene-expression-patterns-x-ray <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--project.html.twig x field--node--title.html.twig * field--node--project.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Three-dimensional imaging of gene expression patterns by x-ray computed tomography</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--uid--project.html.twig x field--node--uid.html.twig * field--node--project.html.twig * field--uid.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--uid.html.twig' --> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'username' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/user/username.html.twig' --> <span lang="" about="/index.php/de/user/31" typeof="schema:Person" property="schema:name" datatype="" content="Maria Garcia Hernandez">Maria Garcia H…</span> <!-- END OUTPUT from 'core/themes/classy/templates/user/username.html.twig' --> </span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--uid.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--created--project.html.twig x field--node--created.html.twig * field--node--project.html.twig * field--created.html.twig * field--created.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--created.html.twig' --> <span class="field field--name-created field--type-created field--label-hidden">Do, 07.03.2019 - 13:43</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--created.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-summary--project.html.twig * field--node--field-summary.html.twig * field--node--project.html.twig * field--field-summary.html.twig x field--text-long.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--text-long.html.twig' --> <div class="clearfix text-formatted field field--name-field-summary field--type-text-long field--label-hidden field__item"><p><span lang="EN-US" xml:lang="EN-US" xml:lang="EN-US"><span><span>This project is aimed to visualize 3D gene expressions of large and opaque biological samples by means of X-ray contrast – combining the knowledge of traditional molecular biology and physics. An advanced imaging method allows for a new way of looking at gene expressions by giving a general, automated high-throughput method of showing complete 3D expression data of genes with a resolution down to the subcellular level, achievable even in large specimen up to complete animals without the need for any sectioning or mechanical manipulation. We demonstrated the performance of this new imaging modality on GFP-tagged reporter lines of the medaka fish. Particularly, we visualized stem cell markers in adult medaka fish organs, such as <em>sox9b</em> and the vascular system where the <em>fli</em> gene is tagged. </span></span></span></p></div> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--text-long.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: x links--node.html.twig x links--node.html.twig * links.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/content/links--node.html.twig' --> <!-- END OUTPUT from 'core/themes/classy/templates/content/links--node.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-bridges--project.html.twig * field--node--field-research-bridges.html.twig * field--node--project.html.twig * field--field-research-bridges.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-research-bridges field--type-entity-reference field--label-above"> <div class="field__label">Forschungsbrücken</div> <div class="field__items"> <div class="field__item"><a href="/index.php/en/research/advanced-imaging-platform-aip" hreflang="en">Advanced Imaging Platform (AIP)</a></div> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-contact-person--project.html.twig * field--node--field-contact-person.html.twig * field--node--project.html.twig x field--field-contact-person.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field--field-contact-person.html.twig' --> <div class="field field--name-field-contact-person field--type-entity-reference field--label-above"> <div class="field__label"><h3>Project management</h3></div> <div class="field__items"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'node' --> <!-- FILE NAME SUGGESTIONS: * node--83--teaser.html.twig * node--83.html.twig x node--people-profile--teaser.html.twig * node--people-profile.html.twig * node--teaser.html.twig * node.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <article data-history-node-id="83" role="article" lang="en" about="/index.php/en/prof-dr-joachim-wittbrodt" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/index.php/en/prof-dr-joachim-wittbrodt" rel="bookmark"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--people-profile.html.twig x field--node--title.html.twig * field--node--people-profile.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Prof. Dr. Joachim Wittbrodt</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> </a> </h2> </div> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-function-1--people-profile.html.twig * field--node--field-function-1.html.twig * field--node--people-profile.html.twig * field--field-function-1.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-function-1 field--type-string field--label-hidden field__item">Director Research Bridge SB</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-institute--people-profile.html.twig * field--node--field-institute.html.twig * field--node--people-profile.html.twig * field--field-institute.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Centre for Organismal Studies Heidelberg (COS)</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-facility--people-profile.html.twig * field--node--field-facility.html.twig * field--node--people-profile.html.twig * field--field-facility.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">Heidelberg University</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-link--people-profile.html.twig * field--node--field-link.html.twig * field--node--people-profile.html.twig * field--field-link.html.twig * field--link.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="https://www.uni-heidelberg.de/izn/researchgroups/wittbrodt/">Research Group Wittbrodt</a></div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> </div> </div> </article> <!-- END OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'node' --> <!-- FILE NAME SUGGESTIONS: * node--233--teaser.html.twig * node--233.html.twig x node--people-profile--teaser.html.twig * node--people-profile.html.twig * node--teaser.html.twig * node.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <article data-history-node-id="233" role="article" lang="en" about="/index.php/en/prof-dr-tilo-baumbach" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/index.php/en/prof-dr-tilo-baumbach" rel="bookmark"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--people-profile.html.twig x field--node--title.html.twig * field--node--people-profile.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Prof. Dr. Tilo Baumbach</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> </a> </h2> </div> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-institute--people-profile.html.twig * field--node--field-institute.html.twig * field--node--people-profile.html.twig * field--field-institute.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Institute for Photon Science and Synchrotron Radiation</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-facility--people-profile.html.twig * field--node--field-facility.html.twig * field--node--people-profile.html.twig * field--field-facility.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">KIT</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-link--people-profile.html.twig * field--node--field-link.html.twig * field--node--people-profile.html.twig * field--field-link.html.twig * field--link.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="http://www.ips.kit.edu/2890_Tilo-Baumbach.php">Contact</a></div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> </div> </div> </article> <!-- END OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field--field-contact-person.html.twig' --> Thu, 07 Mar 2019 12:43:38 +0000 Maria Garcia Hernandez 245 at https://www.heika-research.de On-Chip Fabrication of 3D Bio-Polymer µ-Arrays for Correlative “Cell Clinic” https://www.heika-research.de/en/research/advanced-imaging-platform-aip/chip-fabrication-3d-bio-polymer-m-arrays-correlative-cell <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--project.html.twig x field--node--title.html.twig * field--node--project.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">On-Chip Fabrication of 3D Bio-Polymer µ-Arrays for Correlative “Cell Clinic”</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--uid--project.html.twig x field--node--uid.html.twig * field--node--project.html.twig * field--uid.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--uid.html.twig' --> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'username' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/user/username.html.twig' --> <span lang="" about="/index.php/de/user/31" typeof="schema:Person" property="schema:name" datatype="" content="Maria Garcia Hernandez">Maria Garcia H…</span> <!-- END OUTPUT from 'core/themes/classy/templates/user/username.html.twig' --> </span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--uid.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--created--project.html.twig x field--node--created.html.twig * field--node--project.html.twig * field--created.html.twig * field--created.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--created.html.twig' --> <span class="field field--name-created field--type-created field--label-hidden">Do, 10.12.2020 - 15:10</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--created.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-summary--project.html.twig * field--node--field-summary.html.twig * field--node--project.html.twig * field--field-summary.html.twig x field--text-long.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--text-long.html.twig' --> <div class="clearfix text-formatted field field--name-field-summary field--type-text-long field--label-hidden field__item"><p><span><span><span>It is well established that human pluripotent stem cells undergo apoptosis unless making colonies. Tanaka<strong> </strong><em>et al.</em> recently reported that the adhesiveness of human induced pluripotent stem (hiPS) cells to the surrounding environment critically regulates their functions, but the screening of adhesiveness for the control of lineage-specific differentiation is still challenging. The overarching goal of the HEiKA project is to establish a high throughput microfluidic platform <em>CELL CLINIC</em> for human induced pluripotent stem (hiPS) cells by uniting the expertise of a <strong>microsystem engineer (Badilita, KIT)</strong> and a <strong>biophysicist (Tanaka, HD)</strong>. </span></span></span></p> <p><span><span><span>Tailor made bio-polymer µ-arrays on a chip:</span></span></span></p> <p><span><span><span>The uniqueness of our approach is the ability to fabricate µ-arrays of 3D bio-polymer with tunable adhesiveness by electrodeposition of chitosan derivatives on individually accessible µ-electrodes integrated in a microfluidic device developed by Badilita<strong> </strong>et al. [Badilita2019a]. Badilita et al. also recently reported synthesis of carbon composites from electrodeposited chitosan precursor for various sensing applications [Badilita2020a].</span></span></span></p> <p><span><span><span>Correlative analytical platform:</span></span></span></p> <p><span><span><span>In this project we will take the following three approaches:</span></span></span></p> <ol> <li><span><span><span>quantification of cell <strong>adhesion strength</strong> by morphometric analysis and atomic force microscopy (<strong>Tanaka</strong>),</span></span></span></li> <li><span><span><span>electrochemical monitoring of <strong>colony forming capability</strong> by cyclic voltammetry and impedance spectroscopy (<strong>Tanaka</strong>), and</span></span></span></li> <li><span><span><span>assessment of <strong>metabolic functions </strong>using µ-NMR [Badilita2019] (<strong>Badilita</strong>).</span></span></span></li> </ol> <p><span lang="EN-US" xml:lang="EN-US" xml:lang="EN-US"><span><span>As Tanaka also has a track record in X-ray imaging [Tanaka2020a], we plan to apply for a DFG project to integrate our <em>CELL CLINIC</em> into <strong>KORREL Lab (IMT/KIT) for correlative NMR &amp; X-ray measurements</strong>.</span></span></span></p></div> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--text-long.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: x links--node.html.twig x links--node.html.twig * links.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/content/links--node.html.twig' --> <!-- END OUTPUT from 'core/themes/classy/templates/content/links--node.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-bridges--project.html.twig * field--node--field-research-bridges.html.twig * field--node--project.html.twig * field--field-research-bridges.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-research-bridges field--type-entity-reference field--label-above"> <div class="field__label">Forschungsbrücken</div> <div class="field__items"> <div class="field__item"><a href="/index.php/en/research/advanced-imaging-platform-aip" hreflang="en">Advanced Imaging Platform (AIP)</a></div> <div class="field__item"><a href="/index.php/en/research/functional-materials-fm" hreflang="en">Functional Materials (FM)</a></div> <div class="field__item"><a href="/index.php/en/research/synthetic-biology-sb" hreflang="en">Synthetic Biology (SB)</a></div> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: x field--node--field-start-date--project.html.twig * field--node--field-start-date.html.twig * field--node--project.html.twig * field--field-start-date.html.twig * field--datetime.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field--node--field-start-date--project.html.twig' --> <div class="field field--name-field-start-date field--type-datetime field--label-above"> <div class="field__label">Start date</div> <div class="field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> <time datetime="2021-01-01T12:00:00Z" class="datetime">01.01.2021</time> <!-- END OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field--node--field-start-date--project.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-end-date--project.html.twig * field--node--field-end-date.html.twig * field--node--project.html.twig * field--field-end-date.html.twig * field--datetime.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-end-date field--type-datetime field--label-hidden field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> <time datetime="2021-12-31T12:00:00Z" class="datetime">31.12.2021</time> <!-- END OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-contact-person--project.html.twig * field--node--field-contact-person.html.twig * field--node--project.html.twig x field--field-contact-person.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field--field-contact-person.html.twig' --> <div class="field field--name-field-contact-person field--type-entity-reference field--label-above"> <div class="field__label"><h3>Project management</h3></div> <div class="field__items"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'node' --> <!-- FILE NAME SUGGESTIONS: * node--319--teaser.html.twig * node--319.html.twig x node--people-profile--teaser.html.twig * node--people-profile.html.twig * node--teaser.html.twig * node.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <article data-history-node-id="319" role="article" lang="en" about="/index.php/en/prof-dr-motomu-tanaka" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/index.php/en/prof-dr-motomu-tanaka" rel="bookmark"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--people-profile.html.twig x field--node--title.html.twig * field--node--people-profile.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Prof. Dr. Motomu Tanaka</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> </a> </h2> </div> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-institute--people-profile.html.twig * field--node--field-institute.html.twig * field--node--people-profile.html.twig * field--field-institute.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Institute for Physical Chemistry</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-facility--people-profile.html.twig * field--node--field-facility.html.twig * field--node--people-profile.html.twig * field--field-facility.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">University of Heidelberg</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-link--people-profile.html.twig * field--node--field-link.html.twig * field--node--people-profile.html.twig * field--field-link.html.twig * field--link.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="https://www.pci.uni-heidelberg.de/bpc2/contact.html">Motomu Tanaka</a></div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> </div> </div> </article> <!-- END OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'node' --> <!-- FILE NAME SUGGESTIONS: * node--320--teaser.html.twig * node--320.html.twig x node--people-profile--teaser.html.twig * node--people-profile.html.twig * node--teaser.html.twig * node.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <article data-history-node-id="320" role="article" lang="en" about="/index.php/en/dr-vlad-badilita" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/index.php/en/dr-vlad-badilita" rel="bookmark"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--people-profile.html.twig x field--node--title.html.twig * field--node--people-profile.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Dr. Vlad Badilita</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> </a> </h2> </div> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-institute--people-profile.html.twig * field--node--field-institute.html.twig * field--node--people-profile.html.twig * field--field-institute.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Institute of Microstructure Technology</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-facility--people-profile.html.twig * field--node--field-facility.html.twig * field--node--people-profile.html.twig * field--field-facility.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">Karlsruhe Institute of Technology</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-link--people-profile.html.twig * field--node--field-link.html.twig * field--node--people-profile.html.twig * field--field-link.html.twig * field--link.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="https://www.imt.kit.edu/1035_261.php">Vlad Badilita</a></div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> </div> </div> </article> <!-- END OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field--field-contact-person.html.twig' --> Thu, 10 Dec 2020 14:10:21 +0000 Maria Garcia Hernandez 333 at https://www.heika-research.de Neue Methode zur Feedback-basierten Segmentierung und Visualisierung von komplexen 3D-Bilddatensätzen https://www.heika-research.de/en/research/advanced-imaging-platform-aip/neue-methode-zur-feedback-basierten-segmentierung-und <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--project.html.twig x field--node--title.html.twig * field--node--project.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Neue Methode zur Feedback-basierten Segmentierung und Visualisierung von komplexen 3D-Bilddatensätzen</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--uid--project.html.twig x field--node--uid.html.twig * field--node--project.html.twig * field--uid.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--uid.html.twig' --> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'username' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/user/username.html.twig' --> <span lang="" about="/index.php/de/user/31" typeof="schema:Person" property="schema:name" datatype="" content="Maria Garcia Hernandez">Maria Garcia H…</span> <!-- END OUTPUT from 'core/themes/classy/templates/user/username.html.twig' --> </span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--uid.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--created--project.html.twig x field--node--created.html.twig * field--node--project.html.twig * field--created.html.twig * field--created.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--created.html.twig' --> <span class="field field--name-created field--type-created field--label-hidden">Do, 19.08.2021 - 16:16</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--created.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-summary--project.html.twig * field--node--field-summary.html.twig * field--node--project.html.twig * field--field-summary.html.twig x field--text-long.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--text-long.html.twig' --> <div class="clearfix text-formatted field field--name-field-summary field--type-text-long field--label-hidden field__item"><p><span><span><span><span lang="EN-US" xml:lang="EN-US" xml:lang="EN-US">In the present contribution, we introduced a new approach for improved semi-automatic segmentation of large-scale 3D image stacks. The method does not require tedious parameter tuning and can help to significantly speed up segmentation tasks in scenarios where entirely automated processing is impossible. By propagating manual annotations to adjacent slices and by using sophisticated correction, a close to error-free segmentation can be achieved.</span></span></span></span></p> <p><span><span><span><span lang="EN-US" xml:lang="EN-US" xml:lang="EN-US">Further work will be put on the development of a graphical user interface that condenses all involved workflow steps and to extend the quantification of speed and quality improvements of the proposed segmentation approach. To improve the interactivity and usability of the framework we plan to develop an efficient C++-based application with highly interactive visualisation, editing and prediction capabilities as well as parallel execution of segment propagations in the background. The envisioned application will provide a powerful tool to enable detailed analyses of large-scale 3D microscopic image data sets.</span></span></span></span></p></div> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--text-long.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: x links--node.html.twig x links--node.html.twig * links.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/content/links--node.html.twig' --> <!-- END OUTPUT from 'core/themes/classy/templates/content/links--node.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-bridges--project.html.twig * field--node--field-research-bridges.html.twig * field--node--project.html.twig * field--field-research-bridges.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-research-bridges field--type-entity-reference field--label-above"> <div class="field__label">Forschungsbrücken</div> <div class="field__items"> <div class="field__item"><a href="/index.php/en/research/advanced-imaging-platform-aip" hreflang="en">Advanced Imaging Platform (AIP)</a></div> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: x field--node--field-start-date--project.html.twig * field--node--field-start-date.html.twig * field--node--project.html.twig * field--field-start-date.html.twig * field--datetime.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field--node--field-start-date--project.html.twig' --> <div class="field field--name-field-start-date field--type-datetime field--label-above"> <div class="field__label">Start date</div> <div class="field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> <time datetime="2015-01-01T12:00:00Z" class="datetime">01.01.2015</time> <!-- END OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field--node--field-start-date--project.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-end-date--project.html.twig * field--node--field-end-date.html.twig * field--node--project.html.twig * field--field-end-date.html.twig * field--datetime.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-end-date field--type-datetime field--label-hidden field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> <time datetime="2015-12-31T12:00:00Z" class="datetime">31.12.2015</time> <!-- END OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-contact-person--project.html.twig * field--node--field-contact-person.html.twig * field--node--project.html.twig x field--field-contact-person.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field--field-contact-person.html.twig' --> <div class="field field--name-field-contact-person field--type-entity-reference field--label-above"> <div class="field__label"><h3>Project management</h3></div> <div class="field__items"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'node' --> <!-- FILE NAME SUGGESTIONS: * node--361--teaser.html.twig * node--361.html.twig x node--people-profile--teaser.html.twig * node--people-profile.html.twig * node--teaser.html.twig * node.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <article data-history-node-id="361" role="article" lang="en" about="/index.php/en/prof-dr-heike-leitte" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/index.php/en/prof-dr-heike-leitte" rel="bookmark"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--people-profile.html.twig x field--node--title.html.twig * field--node--people-profile.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Prof. Dr. Heike Leitte</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> </a> </h2> </div> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-institute--people-profile.html.twig * field--node--field-institute.html.twig * field--node--people-profile.html.twig * field--field-institute.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Interdisciplinary Center for Scientific Computing (IWR)</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-facility--people-profile.html.twig * field--node--field-facility.html.twig * field--node--people-profile.html.twig * field--field-facility.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">University of Heidelberg</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> </div> </div> </article> <!-- END OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'node' --> <!-- FILE NAME SUGGESTIONS: * node--362--teaser.html.twig * node--362.html.twig x node--people-profile--teaser.html.twig * node--people-profile.html.twig * node--teaser.html.twig * node.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <article data-history-node-id="362" role="article" lang="en" about="/index.php/en/apl-prof-dr-markus-reischl" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/index.php/en/apl-prof-dr-markus-reischl" rel="bookmark"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--people-profile.html.twig x field--node--title.html.twig * field--node--people-profile.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">apl. Prof. Dr. Markus Reischl</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> </a> </h2> </div> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-institute--people-profile.html.twig * field--node--field-institute.html.twig * field--node--people-profile.html.twig * field--field-institute.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Institut für Automation und angewandte Informatik (IAI)</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-facility--people-profile.html.twig * field--node--field-facility.html.twig * field--node--people-profile.html.twig * field--field-facility.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">Karlsruhe Institute of Technology</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> </div> </div> </article> <!-- END OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field--field-contact-person.html.twig' --> Thu, 19 Aug 2021 14:16:48 +0000 Maria Garcia Hernandez 363 at https://www.heika-research.de Towards High-Performance Printed Thermoelectronics: Enhancing Interfacial Charge Transport via Dynamic Charging Map Analysis https://www.heika-research.de/en/research/advanced-imaging-platform-aip/towards-high-performance-printed-thermoelectronics-enhancing <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--project.html.twig x field--node--title.html.twig * field--node--project.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Towards High-Performance Printed Thermoelectronics: Enhancing Interfacial Charge Transport via Dynamic Charging Map Analysis</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--uid--project.html.twig x field--node--uid.html.twig * field--node--project.html.twig * field--uid.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--uid.html.twig' --> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'username' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/user/username.html.twig' --> <span lang="" about="/index.php/de/user/31" typeof="schema:Person" property="schema:name" datatype="" content="Maria Garcia Hernandez">Maria Garcia H…</span> <!-- END OUTPUT from 'core/themes/classy/templates/user/username.html.twig' --> </span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--uid.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--created--project.html.twig x field--node--created.html.twig * field--node--project.html.twig * field--created.html.twig * field--created.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--created.html.twig' --> <span class="field field--name-created field--type-created field--label-hidden">Di, 16.01.2024 - 17:34</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--created.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-summary--project.html.twig * field--node--field-summary.html.twig * field--node--project.html.twig * field--field-summary.html.twig x field--text-long.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--text-long.html.twig' --> <div class="clearfix text-formatted field field--name-field-summary field--type-text-long field--label-hidden field__item"><p><span><span><span><span lang="EN-US" xml:lang="EN-US" xml:lang="EN-US">Every year, two thirds of primary energy is released to the environment as waste heat. The re-utilization of the enormous amount of waste heat by means of conversion into electricity is of great significance to fight against climate change. </span>Thermoelectric generators (TEGs) have therefore gained a large interest in both academia and industry. Large-scale manufacturing of low-cost shape-versatile TEGs is almost non-feasible by the well-estabilished bulk approaches, while implementing printing technology is a promising solution. To make conventional bulk thermoelectric (TE) materials printable, in other words, to enhance the rheological property of the TE inks, adding inorganic and polymeric binding components and solvents are necessary. These additional components, however, arise new issues with respect to interfacial transport. A high interface resistance and consequently a low device performance are now the main obstacles for printed TEGs to overcome.</span></span></span></p> <p><span lang="EN-GB" xml:lang="EN-GB" xml:lang="EN-GB"><span>In this project, we aim to develop new printed composite TE films with low interface resistance. To this end, site-specific analysis of charge-carrier transport at the interface is essential. Based on the complementary fields of expertise of the Heidelberg and KIT partners, this project will combine the formulation optimization of TE films (KIT group) and the electron-microscopic and -spectroscopic analysis (Heidelberg group). New TE inks will be designed, prepared and printed into TE thin-films, while their microstructure and interfaces within TE thin-films will be analysed in morphological and charge-transport perspectives. A correlation between the microstructural properties at the interfaces and the performance of the printed films will be established. The findings will pave the way to discovering new combinations of the TE phases in the printed films with high charge-transport performance.</span></span></p></div> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--text-long.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: x links--node.html.twig x links--node.html.twig * links.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/content/links--node.html.twig' --> <!-- END OUTPUT from 'core/themes/classy/templates/content/links--node.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-bridges--project.html.twig * field--node--field-research-bridges.html.twig * field--node--project.html.twig * field--field-research-bridges.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-research-bridges field--type-entity-reference field--label-above"> <div class="field__label">Forschungsbrücken</div> <div class="field__items"> <div class="field__item"><a href="/index.php/en/research/advanced-imaging-platform-aip" hreflang="en">Advanced Imaging Platform (AIP)</a></div> <div class="field__item"><a href="/index.php/en/research/functional-materials-fm" hreflang="en">Functional Materials (FM)</a></div> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: x field--node--field-start-date--project.html.twig * field--node--field-start-date.html.twig * field--node--project.html.twig * field--field-start-date.html.twig * field--datetime.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field--node--field-start-date--project.html.twig' --> <div class="field field--name-field-start-date field--type-datetime field--label-above"> <div class="field__label">Start date</div> <div class="field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> <time datetime="2024-01-01T12:00:00Z" class="datetime">01.01.2024</time> <!-- END OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field--node--field-start-date--project.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-end-date--project.html.twig * field--node--field-end-date.html.twig * field--node--project.html.twig * field--field-end-date.html.twig * field--datetime.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-end-date field--type-datetime field--label-hidden field__item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> <time datetime="2024-12-31T12:00:00Z" class="datetime">31.12.2024</time> <!-- END OUTPUT from 'core/themes/classy/templates/field/time.html.twig' --> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-contact-person--project.html.twig * field--node--field-contact-person.html.twig * field--node--project.html.twig x field--field-contact-person.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field--field-contact-person.html.twig' --> <div class="field field--name-field-contact-person field--type-entity-reference field--label-above"> <div class="field__label"><h3>Project management</h3></div> <div class="field__items"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'node' --> <!-- FILE NAME SUGGESTIONS: * node--433--teaser.html.twig * node--433.html.twig x node--people-profile--teaser.html.twig * node--people-profile.html.twig * node--teaser.html.twig * node.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <article data-history-node-id="433" role="article" lang="en" about="/index.php/en/dr-wen-shan-zhang" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/index.php/en/dr-wen-shan-zhang" rel="bookmark"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--people-profile.html.twig x field--node--title.html.twig * field--node--people-profile.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Dr. Wen-Shan Zhang</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> </a> </h2> </div> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-institute--people-profile.html.twig * field--node--field-institute.html.twig * field--node--people-profile.html.twig * field--field-institute.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">BioQuant</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-facility--people-profile.html.twig * field--node--field-facility.html.twig * field--node--people-profile.html.twig * field--field-facility.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">Heidelberg University</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> </div> </div> </article> <!-- END OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'node' --> <!-- FILE NAME SUGGESTIONS: * node--434--teaser.html.twig * node--434.html.twig x node--people-profile--teaser.html.twig * node--people-profile.html.twig * node--teaser.html.twig * node.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> <article data-history-node-id="434" role="article" lang="en" about="/index.php/en/dr-md-mofasser-mallick" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/index.php/en/dr-md-mofasser-mallick" rel="bookmark"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--people-profile.html.twig x field--node--title.html.twig * field--node--people-profile.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> <span class="field field--name-title field--type-string field--label-hidden">Dr. Md. Mofasser Mallick</span> <!-- END OUTPUT from 'core/themes/classy/templates/field/field--node--title.html.twig' --> </a> </h2> </div> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-institute--people-profile.html.twig * field--node--field-institute.html.twig * field--node--people-profile.html.twig * field--field-institute.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Light Technology Institute (LTI)</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-facility--people-profile.html.twig * field--node--field-facility.html.twig * field--node--people-profile.html.twig * field--field-facility.html.twig * field--string.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">Karlsruhe Institute of Technology</div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field.html.twig' --> </div> </div> </article> <!-- END OUTPUT from 'themes/custom/heika/templates/node/node--people-profile--teaser.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/custom/heika/templates/field/field--field-contact-person.html.twig' --> Tue, 16 Jan 2024 16:34:22 +0000 Maria Garcia Hernandez 446 at https://www.heika-research.de